Regenexx-SD is a same-day, orthopedic stem cell treatment. Your stem cells are harvested and re-injected on the same day; however, the entire treatment will take place over a few days. With Regenexx-SD, our goal is to promote natural healing to damaged areas, from bones and cartilage, to muscles, tendons, and ligaments.

How Does Regenexx-SD Work?

During your first appointment, a U.S board certified physician will conduct a follow-up consultation with you and perform a pre-injection, which contains natural growth factors from your own blood. A couple of days later, the physician will perform a bone marrow aspiration. Then, using proprietary lab techniques, our cell biologists will isolate your bone marrow concentrate (which is made up of mesenchymal stem cells and other cell types). Mesenchymal stem cells can orchestrate various types of repair responses for orthopedic issues.

You will receive a re-injection of your extracted stem cells on the same day as the bone marrow aspiration, and you will receive a post-injection a couple of days later. All injections are completed using advanced image guidance. This allows us to see exactly where your stem cells are being injected, so we can precisely target your problem areas.

Why choose Regenexx-SD?

Our same-day injections are up to 20 times more concentrated than bone marrow concentrates achieved by a bedside centrifuge.

Patients typically choose Regenexx treatment if they are looking for a non-surgical treatment option for an orthopedic injury or condition. Where an issue is limited to just one specific joint or area, a Regenexx physician may recommend Regenexx-SD. Regenexx-SD treatment is likely to provide enough cells to be of use for this level of treatment.

However, if a patient requires treatment of multiple joints, anticipates requiring treatment in future, would like to store their stem cells, or is experiencing a more severe injury or condition, they will typically be recommended for the Regenexx-C (cultured stem cell treatment), which provides more stems cells for treatment.

What’s included in the cost of Regenexx-SD treatment?

Regenexx-SD treatment with Regenexx Cayman starts at US$7,000. The total cost depends on your individual treatment plan.

  • A consultation, evaluation, and diagnostic ultrasound
  • A blood draw
  • A bone marrow aspiration
  • A pre-injection
  • A re-injection of your extracted cells
  • A post-injection

To optimize your outcome, your physician may recommend adjunct treatments, such as bone augmentation or capsular distention, which are priced separately. You may elect to proceed with additional treatment, and these costs will be included on your treatment invoice.

Regenexx-C vs Regenexx-SD

Our clinic offers both Regenexx-SD and Regenexx-C stem cell treatments, but what’s the difference?


  • Cultured procedure
  • Stem cells are cultured, yielding up to 100 – 1,000 times more mesenchymal stem cells (MSC)than SD procedure.
  • Typically yields enough cells for multiple treatments.
  • High dose of mesenchymal stem cells (MSC).
  • Typically, one BMA required for multiple treatments and stem cell storage.
  • BMA is done in advance of the re-injection.
  • Treatment requires two trips to Regenexx Cayman.
  • Stem cell storage available for remaining cells.
  • Exclusive to Regenexx Cayman.


  • Same-day procedure
  • Laboratory processing but no stem cell culture.
  • Typically yields enough cells to treat one to two joints max.
  • Lower dose of MSC than Regenexx-C.
  • Multiple BMAs required for multiple treatments.
  • BMA is done on the same day as cell re-injection.
  • Treatment takes place over one week at your chosen clinic.
  • No cells in storage for future treatments.
  • Offered worldwide.

Regenexx-SD: Next Steps

  1. Send an email to [email protected] or call our patient care team on 1-877-211-3834 (U.S. toll-free), 0-800-041-8772 (U.K. toll-free), or 1-345-943-5900 (Local).
  2. Schedule a phone review or consultation with one of Regenexx Cayman’s U.S. board certified physicians.
  3. The physician will thoroughly review your medical history, imaging, and treatment goals.
  4. You will receive a candidacy rating of good, fair, or poor, so you have a clear understanding of your expected outcome.
  5. Schedule your treatment, so you can reduce pain, improve function, and get back to doing what you love.
  6. Receive Regenexx-SD treatment: your bone marrow aspiration (BMA, pre-injection, re-injection of extracted stem cells, and post-injection.)
  7. International patients receive complimentary transportation to and from the airport, to your Seven Mile Beach (SMB) location, and to all Regenexx Cayman appointments.
  8. Stay along stunning Seven Mile Beach and receive preferred rates at select hotels.

If you have any questions about treatment, please contact our patient care team.


Regenexx-SD treatment starts at US$7,000. The total cost depends on your individual treatment plan.

Please note, Regenexx-SD is not covered by insurance and Regenexx Cayman requires all treatment costs to be paid upfront. However, some health insurance companies may cover the cost of your initial consultation, which means you may be able to claim back the cost of your consultation. Coverage varies depending on the provider and plan, so patients are encouraged to contact their health insurance company directly.

To find out if you’re a candidate for Regenexx-SD stem cell therapy, simply schedule a phone review with a Regenexx Cayman physician. During this phone review, the physician will thoroughly review your medical history, imaging, and discuss your treatment goals with you. You will also be given a candidacy rating of good, fair, or poor, so you have a clear understanding of your expected Regenexx-SD outcome.

Did you know? Patients who receive a poor candidacy rating for Regenexx-SD may be a fair or good candidates for Regenexx-C, our cultured stem cell treatment.

Please contact our patient care team if you are interested in booking a phone review.

Your safety is our priority. Regenexx has published the world’s largest stem cell safety study.

Regenexx-SD is an autologous stem cell therapy, which means we use your own stem cells and there is no risk of immune rejection.

All sample processing is completed in our certified ISO class 7 cleanroom, and our laboratory air is HEPA-filtered. We maintain stringent standards of sterility for clinical products, use aseptic technique, and adhere to strict protective gowning protocols. All lab equipment and surfaces are frequently and thoroughly disinfected.

Like all medical procedures and injections, Regenexx-SD carries some low risk of adverse events; however, Regenexx physicians and staff take all the necessary precautions during procedures to reduce this risk.

Before a bone marrow aspiration (BMA) is performed, the injection site is thoroughly numbed. Around 80% of patients say that the BMA was “comfortable with no major soreness after the procedure.” Many people describe the discomfort during the BMA as a deep pressure, but it is not typically described as painful.

Patients sometimes confuse a bone marrow aspiration with a bone marrow biopsy, which is a much more invasive and painful procedure. If you are feeling anxious, we can provide oral medication to help you relax, or we can arrange conscious sedation (a type of anesthesia).

Prior to treatment, local anesthetic is used to numb your skin. While not everyone perceives pain in the same way, most patients report the re-injection as just mildly to moderately uncomfortable. Your reaction will of course depend on the injection site, your level of pain tolerance, and the number of joints being treated. For anyone who is worried about treatment, oral medication can be given to help you relax, or conscious sedation can be arranged.

Conscious sedation is a form of anesthesia; whereby, you remain conscious and you continue to breathe without assistance. Note: this is NOT full anesthesia.

Conscious sedation is not required; however, the physician might recommend it if you are having a bone augmentation or a Regenexx-C intradiscal treatment.

Some level of discomfort, pain, or aching is common after treatment, and patients will typically experience moderate discomfort 12-48 hours after a stem cell re-injection. This will slowly disappear after a few days.

Mild to moderate swelling post-procedure is also very common; after all, this inflammation is a positive response that means your body is trying to heal itself. Swelling usually begins 1 – 2 days after the re-injection and lasts between 3 – 4 days. Patients may take Tylenol but are asked to avoid NSAIDs.

Your treating physician will provide you with specific post-procedure instructions and rehab protocols. But you should certainly try and take it easy for the first 12-24 hours post-procedure. If you are pain and symptom-free, you can go on to slowly test the area with “activity-as-tolerated.”

Many patients report being able to do light activities within one week of treatment. Patients can also typically get back to doing more dynamic exercise 6 to 8 weeks after Regenexx-SD. Active patients report being able to push themselves back to their higher activity levels from weeks 8 to 12.

Patients typically report modest improvement one-month post-procedure and notice continuous improvement for many months thereafter. Regenexx patient outcome data suggests that peak functionality for most patients is between 1-2 years after treatment.

Like all medical procedures, Regenexx procedures have a success and failure rate, and not everyone will experience the same results. Results may vary based on an individual’s overall condition, health, the number and frequency of stem cell therapies, and recovery response time. Depending on the underlying condition, some patients see significant improvement after one treatment, while others elect to have "top-up" treatment in the future.

It is unlikely that you will have enough cells to adequately treat multiple joints with Regenexx-SD, as there are several factors to consider, which may make treatment of multiple joints difficult. For example, we often find that there is not a high enough cell yield from a single bone marrow aspiration (without culture) to provide the cell dosage required to treat multiple joints.

However, it is more likely to be possible to treat multiple joints at the same time with Regenexx-C treatment. The increased cell count from the Regenexx-C culturing process makes it more likely that you can have multiple treatments.

Can I store my remaining cells after the Regenexx-SD procedure?

No. Only cultured stem cells can be stored.

How long do I have to stay in the Cayman Islands for Regenexx-SD treatment?

Regenexx-SD treatment only requires one trip to the Cayman Islands, and you will typically be required to stay on island for 7-9 days.

Can I use someone else’s cells for treatment?

No, Regenexx treatments are autologous, which means we use your own stem cells. Similarly, your stem cells cannot be used to treat other patients.

Can Regenexx-SD treat my orthopedic issue?

Regenexx-SD treatment can be used on most joint structures. It is frequently used to treat orthopedic issues, and it is a trusted alternative to orthopedic surgery. To find out if Regenexx-SD can treat your orthopedic condition, please contact our patient care team.

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